GRB7 is required for triple-negative breast cancer cell invasion and survival

被引：45

作者：

Giricz, Orsi ^{[1
]}

Calvo, Veronica ^{[1
]}

Pero, Stephanie C. ^{[2
,3
]}

Krag, David N. ^{[2
,3
]}

Sparano, Joseph A. ^{[4
,5
]}

Kenny, Paraic A. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[2] Univ Vermont, Dept Surg, Burlington, VT 05405 USA

[3] Univ Vermont, Vermont Canc Ctr, Burlington, VT 05405 USA

[4] Albert Einstein Coll Med, Dept Med & Oncol, Bronx, NY 10461 USA

[5] Montefiore Med Ctr, Bronx, NY 10467 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2012年 / 133卷 / 02期

关键词：

GRB7; Adapter proteins; Triple-negative breast cancer; Tumor cell invasion; Receptor tyrosine kinase signaling; SH2; DOMAIN; SIGNAL-TRANSDUCTION; EXPRESSION; PROTEIN; GENE; RECURRENCE; MIGRATION; PEPTIDE; COMPLEX; TARGET;

D O I：

10.1007/s10549-011-1822-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triple-negative breast cancer (TNBC) is a heterogeneous disease that is usually associated with poor prognosis, and frequently associated with the basal-like breast cancer gene expression profile. There are no targeted therapeutic modalities for this disease, and no useful biomarkers. High GRB7 RNA expression levels are associated with an elevated risk of recurrence in patients with operable TNBC treated with standard adjuvant anthracycline and taxane therapy. To determine whether GRB7 is involved in the pathobiology of TNBC, we evaluated the biological effects of GRB7 inhibition in a panel of triple-negative cell lines-MDA-MB-468, MDA-MB-231, HCC70, and T4-2. We found GRB7 inhibition reduced cell motility and invasion of these cell lines and promoted cell death by apoptosis in 3D culture. These data suggest that GRB7 itself, or GRB7-dependent pathways, may prove to be important therapeutic targets in this disease.

引用

页码：607 / 615

页数：9

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