The epidemic behavior of the hepatitis C virus

被引：342

作者：

Pybus, OG ^{[1
]}

Charleston, MA ^{[1
]}

Gupta, S ^{[1
]}

Rambaut, A ^{[1
]}

Holmes, EC ^{[1
]}

Harvey, PH ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

SCIENCE | 2001年 / 292卷 / 5525期

关键词：

D O I：

10.1126/science.1058321

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hepatitis C virus (HCV) is a leading worldwide cause of liver disease. Here, we use a new model of HCV spread to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data. We find significant differences in epidemic behavior among HCV subtypes and suggest that these differences are largely the result of subtype-specific transmission patterns. Our model builds a bridge between the disciplines of population genetics and mathematical epidemiology by using pathogen gene sequences to infer the population dynamic history of an infectious disease.

引用

页码：2323 / 2325

页数：3

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