Haemoglobin oxygen saturation as a biomarker: the problem and a solution

被引：89

作者：

Boas, David A. ^{[1
]}

Franceschini, Maria Angela ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Opt Div,Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2011年 / 369卷 / 1955期

关键词：

near-infrared spectroscopy; haemoglobin oxygen saturation; oxygen metabolism; muscle; breast; brain; NEAR-INFRARED SPECTROSCOPY; DIFFUSE OPTICAL SPECTROSCOPY; PERIPHERAL VASCULAR-DISEASE; MODIFIED GRUBBS EXPONENT; CEREBRAL BLOOD-VOLUME; HEALTHY-HUMAN BRAINS; BREAST-CANCER; CAROTID-ENDARTERECTOMY; NONINVASIVE MEASUREMENT; TRANSCRANIAL DOPPLER;

D O I：

10.1098/rsta.2011.0250

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Near-infrared spectroscopy measures of haemoglobin oxygen saturation are often used as an indicator of sufficient oxygen delivery to assess injury susceptibility and tissue damage. They have also often been used as a surrogate measure of oxygen metabolism. Unfortunately, these measures have generally failed to provide robust indicators of injury and metabolism. In this paper, we first review when haemoglobin oxygen saturation does work as a robust indicator, and then detail when and why it fails for assessing brain injury and breast cancer. Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism.

引用

页码：4407 / 4424

页数：18

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