Impact of Cisplatin on the recent development of Pt coordination chemistry: a case study

被引：165

作者：

Lippert, B ^{[1
]}

机构：

[1] Univ Dortmund, Fachbereich Chem, D-44221 Dortmund, Germany

来源：

COORDINATION CHEMISTRY REVIEWS | 1999年 / 182卷

关键词：

cisplatin; transplatin; nucleobases; coordination chemistry;

D O I：

10.1016/S0010-8545(98)00192-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An overview is presented on recent developments in selected areas of Pt coordination chemistry which were a direct consequence of the discovery of the antitumor activity of cis-Pt(NH3)(2)Cl-2 (Cisplatin). These include complexes of Pt-II with oxygen donor atoms, mixed-valence state Pt compounds as well as diplatinum(III) complexes, and compounds containing nucleobases as well as a limited number of other heterocyclic ligands. Both the potential biological relevance of these compounds and the role cis- and trans-(am)(2)M-II (am = NH3 or amine; M = Pt, Pd) entities are playing in the construction of regularly shaped molecules ('molecular architecture') are briefly outlined. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：263 / 295

页数：33

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