Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila

被引：138

作者：

Simmonds, AJ

Liu, XF

Soanes, KH

Krause, HM

Irvine, KD

Bell, JB ^{[1
]}

机构：

[1] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

[2] Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

[3] Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA

[4] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

来源：

GENES & DEVELOPMENT | 1998年 / 12卷 / 24期

关键词：

Vestigial; Scalloped; Wing; Drosophila; transcription; development;

D O I：

10.1101/gad.12.24.3815

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a tissue-specific transcriptional intermediary factor of Sd.

引用

页码：3815 / 3820

页数：6