Con: Genome-Wide Association Studies Have Not Been Useful in Understanding Asthma

被引：7

作者：

Adcock, Ian M. ^{[1
]}

Barnes, Peter J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2011年 / 184卷 / 06期

关键词：

GENETICS; RISK; PHENOTYPES; VARIANTS; LOCI;

D O I：

10.1164/rccm.201103-0446ED

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

[No abstract available]

引用

页码：633 / 636

页数：5

共 35 条

[1]

Hundreds of variants clustered in genomic loci and biological pathways affect human height [J].

Allen, Hana Lango ;

Estrada, Karol ;

Lettre, Guillaume ;

Berndt, Sonja I. ;

Weedon, Michael N. ;

Rivadeneira, Fernando ;

Willer, Cristen J. ;

Jackson, Anne U. ;

Vedantam, Sailaja ;

Raychaudhuri, Soumya ;

Ferreira, Teresa ;

Wood, Andrew R. ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Speliotes, Elizabeth K. ;

Wheeler, Eleanor ;

Soranzo, Nicole ;

Park, Ju-Hyun ;

Yang, Jian ;

Gudbjartsson, Daniel ;

Heard-Costa, Nancy L. ;

Randall, Joshua C. ;

Qi, Lu ;

Smith, Albert Vernon ;

Maegi, Reedik ;

Pastinen, Tomi ;

Liang, Liming ;

Heid, Iris M. ;

Luan, Jian'an ;

Thorleifsson, Gudmar ;

Winkler, Thomas W. ;

Goddard, Michael E. ;

Lo, Ken Sin ;

Palmer, Cameron ;

Workalemahu, Tsegaselassie ;

Aulchenko, Yurii S. ;

Johansson, Asa ;

Zillikens, M. Carola ;

Feitosa, Mary F. ;

Esko, Tonu ;

Johnson, Toby ;

Ketkar, Shamika ;

Kraft, Peter ;

Mangino, Massimo ;

Prokopenko, Inga ;

Absher, Devin ;

Albrecht, Eva ;

Ernst, Florian ;

Glazer, Nicole L. ;

Hayward, Caroline .

NATURE, 2010, 467 (7317) :832-838

[2]

Genomewide association studies in allergy and the influence of ethnicity [J].

Barnes, Kathleen C. .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 10 (05) :427-433

[3]

Clinical phenotypes of asthma [J].

Bel, EH .

CURRENT OPINION IN PULMONARY MEDICINE, 2004, 10 (01) :44-50

[4]

Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy [J].

Bouzigon, Emmanuelle ;

Forabosco, Paola ;

Koppelman, Gerard H. ;

Cookson, William O. C. M. ;

Dizier, Marie-Helene ;

Duffy, David L. ;

Evans, David M. ;

Ferreira, Manuel A. R. ;

Kere, Juha ;

Laitinen, Tarja ;

Malerba, Giovanni ;

Meyers, Deborah A. ;

Moffatt, Miriam ;

Martin, Nicholas G. ;

Ng, Mandy Y. ;

Pignatti, Pier Franco ;

Wjst, Mathias ;

Kauffmann, Francine ;

Demenais, Florence ;

Lewis, Cathryn M. .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2010, 18 (06) :700-706

[5]

Orm family proteins mediate sphingolipid homeostasis [J].

Breslow, David K. ;

Collins, Sean R. ;

Bodenmiller, Bernd ;

Aebersold, Ruedi ;

Simons, Kai ;

Shevchenko, Andrej ;

Ejsing, Christer S. ;

Weissman, Jonathan S. .

NATURE, 2010, 463 (7284) :1048-U65

[6]

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress [J].

Cantero-Recasens, Gerard ;

Fandos, Cesar ;

Rubio-Moscardo, Fanny ;

Valverde, Miguel A. ;

Vicente, Ruben .

HUMAN MOLECULAR GENETICS, 2010, 19 (01) :111-121

[7]

PDE11A associations with asthma: Results of a genome-wide association scan [J].

DeWan, Andrew T. ;

Triche, Elizabeth W. ;

Xu, Xuming ;

Hsu, Ling-I ;

Zhao, Connie ;

Belanger, Kathleen ;

Hellenbrand, Karen ;

Willis-Owen, Saffron A. G. ;

Moffatt, Miriam ;

Cookson, William O. C. ;

Himes, Blanca E. ;

Weiss, Scott T. ;

Gauderman, W. James ;

Baurley, James W. ;

Gilliland, Frank ;

Wilk, Jemma B. ;

O'Connor, George T. ;

Strachan, David P. ;

Hoh, Josephine ;

Bracken, Michael B. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (04) :871-U321

[8]

A genome-wide association study of global gene expression [J].

Dixon, Anna L. ;

Liang, Liming ;

Moffatt, Miriam F. ;

Chen, Wei ;

Heath, Simon ;

Wong, Kenny C. C. ;

Taylor, Jenny ;

Burnett, Edward ;

Gut, Ivo ;

Farrall, Martin ;

Lathrop, G. Mark ;

Abecasis, Goncalo R. ;

Cookson, William O. C. .

NATURE GENETICS, 2007, 39 (10) :1202-1207

[9]

Gene-environment interaction for childhood asthma and exposure to farming in Central Europe [J].

Ege, Markus J. ;

Strachan, David P. ;

Cookson, William O. C. M. ;

Moffatt, Miriam F. ;

Gut, Ivo ;

Lathrop, Mark ;

Kabesch, Michael ;

Genuneit, Jon ;

Buechele, Gisela ;

Sozanska, Barbara ;

Boznanski, Andrzej ;

Cullinan, Paul ;

Horak, Elisabeth ;

Bieli, Christian ;

Braun-Fahrlaender, Charlotte ;

Heederik, Dick ;

von Mutius, Erika .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (01) :138-U226

[10]

Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia [J].

Ferreira, Manuel A. R. ;

McRae, Allan F. ;

Medland, Sarah E. ;

Nyholt, Dale R. ;

Gordon, Scott D. ;

Wright, Margaret J. ;

Henders, Anjali K. ;

Madden, Pamela A. ;

Visscher, Peter M. ;

Wray, Naomi R. ;

Heath, Andrew C. ;

Montgomery, Grant W. ;

Duffy, David L. ;

Martin, Nicholas G. .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2011, 19 (04) :458-464

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