Prognostic implications of the immunophenotype in biphenotypic acute leukemia

被引：42

作者：

Lee, Je-Hwan ^{[3
]}

Min, Yoo Hong ^{[1
]}

Chung, Chul Won ^{[4
]}

Kim, Byoung Kook ^{[5
]}

Yoon, Hwi-Joong ^{[6
]}

Jo, Deog-Yeon ^{[7
]}

Shin, Ho-Jin ^{[8
]}

Bangs, Soo-Mee ^{[9
]}

Won, Jong-Ho ^{[10
]}

Zang, Dae Young ^{[11
]}

Kim, Hyeoung Joon ^{[12
]}

Chi, Hyun-Sook ^{[13
]}

Lee, Kyoo-Hyung ^{[3
]}

Cheong, June-Won ^{[1
]}

Kim, Jin Seok ^{[1
]}

Kim, Sun Hee ^{[14
]}

Park, Seonyang ^{[5
]}

Park, Su Yon ^{[15
]}

Chung, Joo Seop ^{[8
]}

Lee, Jae Hoon ^{[9
]}

Park, Chan-Jeoung ^{[2
,13
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Severance Hosp, Seoul 120752, South Korea

[2] Asan Med Ctr, Dept Lab Med, Seoul 138736, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med, Seoul, South Korea

[5] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[6] Kyung Hee Univ, Sch Med, Med Ctr, Dept Internal Med, Seoul, South Korea

[7] Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Internal Med, Coll Med, Taejon, South Korea

[8] Pusan Natl Univ, Coll Med, Pusan Natl Univ Hosp, Dept Internal Med, Pusan, South Korea

[9] Gachon Univ Med & Sci, Gachon Univ Gil Med Ctr, Dept Internal Med, Inchon, South Korea

[10] Soon Chun Hyang Univ, Coll Med, Soon Chun Hyang Univ Hosp, Dept Internal Med, Seoul, South Korea

[11] Hallym Univ, Coll Med, Dept Internal Med, Anyang, South Korea

[12] Chonnam Natl Univ, Coll Med, Chonnam Natl Univ Hwasun Hosp, Dept Internal Med, Hwasun, South Korea

[13] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Lab Med, Seoul, South Korea

[14] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med, Seoul, South Korea

[15] Kyung Hee Univ, Sch Med, Med Ctr, Dept Lab Med, Seoul, South Korea

来源：

LEUKEMIA & LYMPHOMA | 2008年 / 49卷 / 04期

关键词：

biphenotypic; acute leukemia; immunophenotype;

D O I：

10.1080/10428190701843247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P=0.039) and lower overall survival (0% vs. 33.9% at 5 years, P=0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

引用

页码：700 / 709

页数：10

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