Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells

被引：24

作者：

Cano, Oscar D. ^{[1
]}

Neurauter, Gabriele ^{[2
]}

Fuchs, Dietmar ^{[2
]}

Shearer, Gene M. ^{[1
]}

Boasso, Adriano ^{[1
]}

机构：

[1] NCI, NIH, Expt Immunol Branch, Bethesda, MD 20892 USA

[2] Innsbruck Med Univ, Div Biol Chem, A-6020 Innsbruck, Austria

来源：

NEUROSCIENCE LETTERS | 2008年 / 438卷 / 01期

关键词：

astrocyte-derived cells; neopterin; indoleamine (2,3)-dioxygenase; interferon; amino acids; HIV;

D O I：

10.1016/j.neulet.2008.04.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Intrathecal production of neopterin, a pteridine produced by interferon (IFN)-gamma-stimulated monocyte-derived macrophages, is associated with neurological disorders and infections. We investigated whether IFN-alpha/beta, IFN-gamma, or human immunodeficiency virus (HIV) induce neopterin production by human astroglioma cells. IFN-alpha/beta and IFN-gamma, but not HIV, induced neopterin. Interestingly, IFN-gamma, but not IFN-alpha/beta, increased expression and activity of the tryptophan-catabolizing enzyme indoleamine (2,3)-dioxygenase. In contrast, IFN-alpha/beta, but not IFN-gamma, reduced the uptake of three aromatic amino acids in U87MG and U138 astroglioma cells. Thus type I and type II IFN stimulate astrocyte-derived cells to produce neopterin and exert differential effects on amino acid metabolism. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

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页数：4

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