Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats

被引：78

作者：

Stratford, TR

Kelley, AE

Simansky, KJ

机构：

[1] Med Coll Penn & Hahnemann Univ, Dept Pharmacol, Philadelphia, PA 19129 USA

[2] Univ Wisconsin, Sch Med, Dept Psychiat, Madison, WI 53719 USA

来源：

BRAIN RESEARCH | 1999年 / 825卷 / 1-2期

关键词：

D O I：

10.1016/S0006-8993(99)01239-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

gamma-aminobutyric acid (GABA)-containing fibers from the nucleus accumbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to the lateral hypothalamus (LH). Therefore, the VPm is anatomically interposed between the AcbSh and LH, two functionally related brain regions that mediate food intake. The present study demonstrates that blockade of GABA(A) receptors in the VPm by local administration of bicuculline greatly increases food intake in satiated rats. The data suggest that an AcbSh-VPm-LH circuit may be involved in the control of feeding behavior. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：199 / 203

页数：5

共 23 条

[1]

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