The renin-angiotensin system in blacks: Active, passive, or what?

被引：33

作者：

Price, DA

Fisher, NDL

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CURRENT HYPERTENSION REPORTS | 2003年 / 5卷 / 03期

关键词：

BLOOD-PRESSURE; DIABETIC NEPHROPATHY; RENAL-DISEASE; SERUM ANGIOTENSINOGEN; RACIAL-DIFFERENCES; AFRICAN-AMERICANS; DIETARY-SODIUM; HYPERTENSION; PLASMA; WHITE;

D O I：

10.1007/s11906-003-0025-x

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Plasma renin activity in blacks has been consistently reported to be lower than in whites. Many mechanisms for the low plasma renin activity have been proposed, including volume status, renal sodium handling, and the reduction of renin release. The status of the RAS is paramount in the regulation of salt and water balance and its implications in disease processes such as hypertension and renal failure. In this review, we present data to suggest that law systemic plasma renin activity in blacks may not be the primary abnormality, but rather the reflection of an overactive RAS at the tissue level in the kidney.

引用

页码：225 / 230

页数：6

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