Synthesis of polycyclic lactams and sultams by a cascade ring-closure metathesis/isomerization and subsequent radical cyclization

被引：48

作者：

Bressy, C ^{[1
]}

Menant, C ^{[1
]}

Piva, O ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5181, Lab Chim Organ Photochim & Synthese, F-69622 Villeurbanne, France

来源：

SYNLETT | 2005年 / 04期

关键词：

polycyclic lactams; 2-pyrrolines; ring-closure metathesis;

D O I：

10.1055/s-2004-862386

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from readily available substrates, a new one-pot procedure has been devised to prepare polycyclic lactams and sultams. 2-Pyrrolines obtained from N,N-bisallylamides by ring-closure metathesis and subsequent isomerization promoted by ruthenium hydride complexes can undergo radical cyclization to furnish polycyclic lactams in good yields. The process was successfully conducted on bisallylsulfonamides to give the corresponding sultams.

引用

页码：577 / 582

页数：6

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