Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study

被引：33

作者：

Angenstein, Frank

Kammerer, Elena

Niessen, Heiko G.

Frey, Julietta U.

Scheich, Henning

Frey, Sabine

机构：

[1] Leibniz Inst Neurobiol, Special Lab Non Invas Brain Imaging, D-39118 Magdeburg, Germany

[2] Univ Magdeburg, Dept Neurol 2, D-39106 Magdeburg, Germany

[3] Leibniz Inst Neurobiol, Dept Neurophysiol, Magdeburg, Germany

[4] Leibniz Inst Neurobiol, Dept Auditory Learning & Speech, Magdeburg, Germany

来源：

NEUROIMAGE | 2007年 / 38卷 / 01期

关键词：

D O I：

10.1016/j.neuroimage.2007.07.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Frequency-dependent hippocampal activation during electrical perforant pathway stimulation was analyzed simultaneously by electrophysiological recordings in dentate gyrus and functional magnetic resonance imaging (fMRI). Pulse trains at low-frequency stimulation (2.5 Hz) did not influence electrophysiological responses within stimulation trains in the dentate gyrus and triggered no detectable BOLD responses. Increased stimulation frequencies (5.0-20 Hz) generated a roughly linear enhancement of the BOLD response. The BOLD signal within the dentate gyrus correlated more closely with stimulus pattern than with generated action potentials of the granular cells. However, the BOLD signal was strongly influenced by additional local signal processing activated by repetitive stimulus trains. fMRI visualized a frequency-specific spatial activation pattern of the hippocampus; spatially restricted activation in the dentate gyrus during 5-Hz stimulation, activation of the entire hippocampus and subiculum at 10 Hz and activation of the contralateral hippocampus during 20-Hz stimulation. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：150 / 163

页数：14

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