Does the HBZ gene represent a new potential target for the treatment of adult T-Cell leukemia?

被引：13

作者：

Barbeau, Benoit ^{[1
]}

Mesnard, Jean-Michel ^{[2
,3
]}

机构：

[1] Univ Quebec, Dept Sci Biol, Montreal, PQ, Canada

[2] CPBS, UMR 5236, IFR 122, Montpellier, France

[3] CNRS, UM1, UM2, Inst Biol, Montpellier, France

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2007年 / 26卷 / 5-6期

关键词：

ATL; HBZ; HTLV-1; leukemia;

D O I：

10.1080/08830180701690843

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Links between human T-cell leukemia virus type 1 and adult T-cell leukemia (ATL) were first suspected in 1980. Provirus integration has since been found in all ATL cells. Although the viral Tax protein is involved in the Proliferation of the infected cells during the preleukemic stage, Tax expression is not systematically detected in primary leukemic cells. Recent studies found that the viral HBZ gene was always expressed in leukemic cells, suggesting its involvement in the progression of the infected cells toward malignancy. How could this new discovery be translated into possible new avenues for the prevention or treatment of ATL?.

引用

收藏

页码：283 / 304

页数：22

相关论文

共 106 条

[1] Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter [J].

Agarwal, SK ;

Novotny, EA ;

Crabtree, JS ;

Weitzman, JB ;

Yaniv, M ;

Burns, AL ;

Chandrasekharappa, SC ;

Collins, FS ;

Spiegel, AM ;

Marx, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10770-10775

[2] Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis [J].

Albrecht, B ;

Lairmore, MD .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (03) :396-+

[3]

ALEXANDRE C, 1991, ONCOGENE, V6, P543

[4] Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1 [J].

Arnold, Joshua ;

Yamamoto, Brenda ;

Li, Min ;

Phipps, Andrew J. ;

Younis, Ihab ;

Lairmore, Michael D. ;

Green, Patrick L. .

BLOOD, 2006, 107 (10) :3976-3982

[5] Is human T-cell lymphotropic virus type I really silent? [J].

Asquith, B ;

Hanon, E ;

Taylor, GP ;

Bangham, CRM .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2000, 355 (1400) :1013-1019

[6] In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection [J].

Asquith, Becca ;

Zhang, Yan ;

Mosley, Angelina J. ;

de lara, Catherine M. ;

Wallace, Diana L. ;

Worth, Andrew ;

Kaftantzi, Lambrini ;

Meekings, Kiran ;

Griffin, George E. ;

Tanakall, Yuetsu ;

Toughfi, David F. ;

Beverley, Peter C. ;

Taylorl, Graham P. ;

Macallant, Derek C. ;

Bangham, Charles R. M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) :8035-8040

[7] The central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerization [J].

Basbous, J ;

Bazarbachi, A ;

Granier, C ;

Devaux, C ;

Mesnard, JM .

JOURNAL OF VIROLOGY, 2003, 77 (24) :13028-13035

[8] The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity [J].

Basbous, J ;

Arpin, C ;

Gaudray, G ;

Piechaczyk, M ;

Devaux, C ;

Mesnard, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) :43620-43627

[9] Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains [J].

Baydoun, Hicham ;

Duc-Dodon, Madeleine ;

Lebrun, Sylvie ;

Gazzolo, Louis ;

Bex, Francoise .

GENE, 2007, 386 (1-2) :191-201

[10]

BENVENISTY N, 1992, ONCOGENE, V7, P2399

← 1 2 3 4 5 6 7 8 9 10 →