The kapakahines, cyclic peptides from the marine sponge Cribrochalina olemda

被引：86

作者：

Yeung, BKS

Nakao, Y

Kinnel, RB

Carney, JR

Yoshida, WY

Scheuer, PJ

KellyBorges, M

机构：

[1] UNIV HAWAII MANOA,DEPT CHEM,HONOLULU,HI 96822

[2] HARBOR BRANCH OCEANOG INST INC,FT PIERCE,FL 34936

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 20期

关键词：

D O I：

10.1021/jo960725e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four cyclic peptides, kapakahines A-D, were isolated from the marine sponge Cribrochalina olemda. Their structures including complete stereochemistry were elucidated by spectral analysis and chemical degradation. The unique structural feature of these peptides is the lack of an amide linkage between two tryptophan residues. Instead the ring is closed by a bond from the indole nitrogen of Trp-1 to the beta-carbon of Trp-2.

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页码：7168 / 7173

页数：6

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