Specificities of B cell reactions to drugs - The penicillin model

被引：9

作者：

Blanca, M

Cornejo-Garcia, JA

Torres, MJ

Mayorga, C

机构：

[1] Carlos Haya Hosp, Allergy Serv, Malaga 29009, Spain

[2] Carlos Haya Hosp, Res Unit Allerg Dis, Malaga 29009, Spain

来源：

TOXICOLOGY | 2005年 / 209卷 / 02期

关键词：

penicillin G; amoxicillin; IgE; immedite hypersensitivity;

D O I：

10.1016/j.tox.2004.12.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Betalactams conjugate to protein carriers induced T and B cell effector responses. From these, IgE dependent reactions are the most common and better defined. These antibodies recognize a number of structures that can cross react or selective recognition may occur. The great variability in the chemical structure, specifically at the position R of penicillin and RI of cephallosporins has made that the recognition of these structures may have clinical relevance in the evaluation of patients allergic to betalactams. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：181 / 184

页数：4

共 19 条

[1]

AHLSTEDT S, 1982, PROG ALLERGY, V30, P67

[2]

Amos HE, 1976, ALLERGIC DRUG REACTI, P1

[3] PENICILLIN ALLERGY - FORMATION OF PENICILLOYL DETERMINANT [J].

BATCHELO.FR ;

DEWDNEY, JM ;

GAZZARD, D .

NATURE, 1965, 206 (4982) :362-&

[4]

BATCHELOR F, 1967, LANCET, V2, P1175

[5] ALLERGY TO PENICILLIN WITH GOOD TOLERANCE TO OTHER PENICILLINS - STUDY OF THE INCIDENCE IN SUBJECTS ALLERGIC TO BETA-LACTAMS [J].

BLANCA, M ;

VEGA, JM ;

GARCIA, J ;

CARMONA, MJ ;

TERADOS, S ;

AVILA, MJ ;

MIRANDA, A ;

JUAREZ, C .

CLINICAL AND EXPERIMENTAL ALLERGY, 1990, 20 (05) :475-481

[6]

Blanca M, 1996, CLIN EXP ALLERGY, V26, P335

[7] 3 EPITOPE-SPECIFIC MONOCLONAL-ANTIBODIES AGAINST THE HAPTEN PENICILLIN [J].

DEHAAN, P ;

DEJONGE, AJR ;

VERBRUGGE, T ;

BOORSMA, DM .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1985, 76 (01) :42-46

[8]

DEWDENEY JM, 1977, ANTIGENS, V5, P173

[9]

DEWECK AL, 1983, ALLERGIC REACTIONS D, V63, P75

[10]

LEVINE BB, 1964, IMMUNOLOGY, V7, P542

← 1 2 →