Microscope-based static light-scattering instrument

被引:31
作者
Valentine, MT [1 ]
Popp, AK
Weitz, DA
Kaplan, PD
机构
[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA
[2] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA
[3] Unilever Res, Edgewater, NJ USA
关键词
D O I
10.1364/OL.26.000890
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We describe a new design for a microscope-based static light-scattering instrument that provides simultaneous high-resolution images and static light-scattering data. By correlating real space images with scattering patterns, we can interpret measurements from heterogeneous samples, which we illustrate by using biological tissue. (C) 2001 Optical Society of America.
引用
收藏
页码:890 / 892
页数:3
相关论文
共 16 条
[1]   Time-Resolved Spectroscopy of mitochondria, cells and tissues under normal and pathological conditions [J].
Beauvoit, B ;
Chance, B .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 184 (1-2) :445-455
[2]   QUASI-ELASTIC LIGHT-SCATTERING MICROSCOPE SPECTROMETER [J].
BLANK, PS ;
TISHLER, RB ;
CARLSON, FD .
APPLIED OPTICS, 1987, 26 (02) :351-356
[3]  
Burger D. E., 1979, Proceedings of the Society of Photo-Optical Instrumentation Engineers, V190, P467
[4]   Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject [J].
Fishkin, JB ;
Coquoz, O ;
Anderson, ER ;
Brenner, M ;
Tromberg, BJ .
APPLIED OPTICS, 1997, 36 (01) :10-20
[5]   Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues [J].
Hielscher, AH ;
Alcouffe, RE ;
Barbour, RL .
PHYSICS IN MEDICINE AND BIOLOGY, 1998, 43 (05) :1285-1302
[6]  
Inoue S., 1997, Video Microscopy: The Fundamentals, V2nd
[7]   Light-scattering microscope [J].
Kaplan, PD ;
Trappe, V ;
Weitz, CA .
APPLIED OPTICS, 1999, 38 (19) :4151-4157
[8]   In vivo measurements of the wavelength dependence of tissue-scattering coefficients between 760 and 900 nm measured with time-resolved spectroscopy [J].
Matcher, SJ ;
Cope, M ;
Delpy, DT .
APPLIED OPTICS, 1997, 36 (01) :386-396
[9]   Spectroscopic diagnosis of bladder cancer with elastic light scattering [J].
Mourant, JR ;
Bigio, IJ ;
Boyer, J ;
Conn, RL ;
Johnson, T ;
Shimada, T .
LASERS IN SURGERY AND MEDICINE, 1995, 17 (04) :350-357
[10]   HEMOGLOBIN AGGREGATION IN SINGLE RED-BLOOD-CELLS OF SICKLE-CELL-ANEMIA [J].
NISHIO, I ;
TANAKA, T ;
SUN, ST ;
IMANISHI, Y ;
OHNISHI, ST .
SCIENCE, 1983, 220 (4602) :1173-1175