N4-Phenyl modifications N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

被引：30

作者：

Huang, Wenwei

Zheng, Wei

Urban, Daniel J.

Inglese, James

Sidransky, Ellen

Austin, Christopher P.

Thomas, Craig J.

机构：

[1] NIH, NIH Chem Genome Ctr, Natl Human Genome Res Inst, Bethesda, MD 20892 USA

[2] NIH, Natl Human Genome Res Inst, Med Genet Branch, Bethesda, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 21期

关键词：

triazine; Gaucher disease; glucocerebrosidase; chemical chaperone;

D O I：

10.1016/j.bmcl.2007.08.050

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related Sugar hydrolases enzymes are described. Published by Elsevier Ltd.

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收藏

页码：5783 / 5789

页数：7

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