Epigenetic regulation of the neural transcriptome: the meaning of the marks

被引：154

作者：

Meaney, Michael J. ^{[1
,3
]}

Ferguson-Smith, Anne C. ^{[2
,3
]}

机构：

[1] McGill Univ, Douglas Hosp Mental Hlth Univ Inst, Sackler Program Epigenet & Psychobiol, Montreal, PQ, Canada

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

[3] Singapore Inst Clin Sci, Singapore, Singapore

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 11期

基金：

英国医学研究理事会;

关键词：

DNA METHYLATION; HUMAN BRAIN; HISTONE H3; CHROMATIN-STRUCTURE; MECP2; CPG; HETEROCHROMATIN; PROMOTER; DISEASE; COMPLEX;

D O I：

10.1038/nn1110-1313

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The field of epigenetics provides neurobiologists with candidate mechanisms for experience-dependent changes in gene transcription. The ability to realize the potential of epigenetics in defining the causal pathways lying between environmental signals, transcriptional regulation and neural function will depend on moving beyond correlational studies focusing on individual epigenetic marks. Here we attempt to provide a conceptual framework for integrative research on nucleotide sequence, chromatin modifications, RNA signaling and their interactions in understanding experience-dependent phenotypic plasticity. Studies in genomic imprinting may serve as an existing model for such approaches.

引用

收藏

页码：1313 / 1318

页数：6

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