Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients

被引:62
作者
Sakurauchi, Y
Matsumoto, Y
Shinzato, T
Takai, I
Nakamura, Y
Sato, M
Nakai, S
Miwa, M
Morita, H
Miwa, T
Amano, I
Maeda, K
机构
[1] Nagoya Univ, Daiko Med Ctr, Dept Internal Med, Higashi Ku, Nagoya, Aichi 461, Japan
[2] Aichi Clin, Toyohashi, Aichi, Japan
[3] Johoku Clin, Nagoya, Aichi, Japan
[4] Shakaihoken Chyukyo Hosp, Dept Hemodialysis, Nagoya, Aichi, Japan
[5] Toyohashi Municipal Hosp, Toyohashi, Aichi, Japan
关键词
L-carnitine supplementation; hemodialysis; muscle symptoms; plasma carnitine levels;
D O I
10.1053/ajkd.1998.v32.pm9708610
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Various muscle symptoms are well recognized among patients on maintenance hemodialysis, Carnitine deficiency may be an important factor of dialysis-associated muscle symptoms, whereas high-dose L-carnitine supplementation may result in unphysiologically high plasma levels of carnitine and carnitine esters. We studied the effect of low-dose L-carnitine treatment (500 mg/d) on muscle symptoms, plasma carnitine fractions, and lipid profiles in 30 periodically dialyzed patients with muscular weakness, fatigue, or cramps/aches. After 12 weeks of L-carnitine treatment, about two-thirds of patients had at least some improvement in muscular symptoms, whereas carnitine fractions were normal or slightly above normal ranges, but lipid profiles showed no demonstrable changes. This study also showed the correlation between plasma-free carnitine deficiency and months on dialysis, These results suggest that prolonged low-dose L-carnitine treatment can improve dialysis-associated muscle symptoms by restoring carnitine tissue levels and washing out acyl moieties. (C) 1998 by the National Kidney Foundation, Inc.
引用
收藏
页码:258 / 264
页数:7
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