Crossed reduction of human motor cortex excitability by 1-Hz transcranial magnetic stimulation

被引：193

作者：

Wassermann, EM

Wedegaertner, FR

Ziemann, U

George, MS

Chen, R

机构：

[1] NINDS, Med Neurol Branch, NIH, Bethesda, MD 20892 USA

[2] Med Univ S Carolina, Dept Radiol, Charleston, SC 29425 USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 250卷 / 03期

关键词：

transcranial magnetic stimulation; motor cortex; basal ganglia; inhibition; long-term depression;

D O I：

10.1016/S0304-3940(98)00437-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Electrophysiological studies have shown that 1-Hz repetitive transcranial magnetic stimulation (rTMS) of the primary motor area (M1) can produce a local decrease in excitability. Functional imaging data suggest that this change may be bilateral. In normal subjects, we measured motor evoked potential (MEP) amplitude at a series of stimulation intensities in the contralateral M1 before and after 15 min of active or sham rTMS at just above the MEP threshold. The slope of the curve relating MEP amplitude and stimulation intensity was decreased in the unstimulated hemisphere by active but not sham rTMS. This demonstrates that rTMS can condition cortical excitability at a distance of one or more synapses and suggest that decreased excitability to TMS is a correlate of decreased blood flow and metabolism. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：141 / 144

页数：4

共 22 条

[1] Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R
Classen, J
Gerloff, C
Celnik, P
Wassermann, EM
Hallett, M
Cohen, LG
[J]. NEUROLOGY, 1997, 48 (05) : 1398 - 1403
[2] FLIP SIDE OF SYNAPTIC PLASTICITY - LONG-TERM DEPRESSION MECHANISMS IN THE HIPPOCAMPUS
CHRISTIE, BR
KERR, DS
ABRAHAM, WC
[J]. HIPPOCAMPUS, 1994, 4 (02) : 127 - 135
[3] INTERHEMISPHERIC INHIBITION OF THE HUMAN MOTOR CORTEX
FERBERT, A
PRIORI, A
ROTHWELL, JC
DAY, BL
COLEBATCH, JG
MARSDEN, CD
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1992, 453 : 525 - 546
[4] Imaging human intra-cerebral connectivity by PET during TMS
Fox, P
Ingham, R
George, MS
Mayberg, H
Ingham, J
Roby, J
Martin, C
Jerabek, P
[J]. NEUROREPORT, 1997, 8 (12) : 2787 - 2791
[5] THE RELATIONSHIP OF CORPUS-CALLOSUM CONNECTIONS TO ELECTRICAL-STIMULATION MAPS OF MOTOR, SUPPLEMENTARY MOTOR, AND THE FRONTAL EYE FIELDS IN OWL MONKEYS
GOULD, HJ
CUSICK, CG
PONS, TP
KAAS, JH
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 247 (03) : 297 - 325
[6] THE BASAL GANGLIA AND ADAPTIVE MOTOR CONTROL
GRAYBIEL, AM
AOSAKI, T
FLAHERTY, AW
KIMURA, M
[J]. SCIENCE, 1994, 265 (5180) : 1826 - 1831
[7] GRAYBIEL AM, 1995, TRENDS NEUROSCI, V18, P60
[8] Building action repertoires: Memory and learning functions of the basal ganglia
Graybiel, AM
[J]. CURRENT OPINION IN NEUROBIOLOGY, 1995, 5 (06) : 733 - 741
[9] Long-term depression of horizontal connections in rat motor cortex
Hess, G
Donoghue, JP
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (04) : 658 - 665
[10] Abnormal cortical motor excitability in dystonia
Ikoma, K
Samii, A
Mercuri, B
Wassermann, EM
Hallett, M
[J]. NEUROLOGY, 1996, 46 (05) : 1371 - 1376

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