Design, synthesis and acaricidal activity of novel strobilurin derivatives containing pyrimidine moieties

被引：51

作者：

Chai, Bao-Shan ^{[1
,2
]}

Liu, Chang-Ling ^{[1
]}

Li, Hui-Chao ^{[1
]}

He, Xiao-Min ^{[1
]}

Luo, Yan-Mei ^{[1
]}

Huang, Guang ^{[1
]}

Zhang, Hong ^{[1
]}

Chang, Jun-Biao ^{[2
]}

机构：

[1] Shenyang Res Inst Chem Ind, State Key Lab Discovery & Dev Novel Pesticide, Shenyang 110021, Peoples R China

[2] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

PEST MANAGEMENT SCIENCE | 2010年 / 66卷 / 11期

关键词：

strobilurin derivatives; pyrimidine; acaricidal activity; intermediate derivatisation method; FUNGICIDAL ACTIVITY;

D O I：

10.1002/ps.1997

中图分类号：

S3 [农学（农艺学）];

学科分类号：

090104 [作物信息科学与技术];

摘要：

BACKGROUND: The intermediate derivatisation method based on bioisosteric replacement led to the discovery of the lead strobilurin compound 5a. To produce new strobilurin analogues with improved activity, a series of substituted pyrimidines were synthesised and bioassayed. RESULTS: The compounds were identified by H-1 NMR, IR, MS and elemental analysis. The highly active compound 5g was studied by X-ray diffraction. Preliminary bioassays demonstrated that some of the title compounds exhibited excellent acaricidal activity against Tetranychus cinnabarinus (Boisd.) at 10 mg L-1. The relationship between structure and acaricidal activity is reported. CONCLUSION: The present work demonstrates that strobilurin derivatives containing pyrimidine moieties can be used as possible lead compounds for developing novel acaricides. (C) 2010 Society of Chemical Industry

引用

页码：1208 / 1214

页数：7

共 24 条

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