Enhanced protection against influenza virus of mice immunized as newborns with a mixture of plasmids expressing hemagglutinin and nucleoprotein

被引：39

作者：

Bot, A ^{[1
]}

Bot, S ^{[1
]}

Bona, C ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

来源：

VACCINE | 1998年 / 16卷 / 17期

关键词：

influenza vaccines; neonatal immunization; DNA vaccine;

D O I：

10.1016/S0264-410X(98)00054-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effective immunization of neonates is an important goal for vaccinology. We show that inoculation of newborn mice with a mixture of plasmids expressing influenza hemagglutinin (HA) and nucleoprotein (NP) genes leads to an enhanced protection subsequent to the lethal challenge with two distinct strains. In sharp contrast neonatal injection with UV-inactivated influenza virus strain WSN, failed to induce protection against the homologous challenge. Our results show that while plasmid immunization of neonates elicits a protective immunity, the immunization with inactivated virus does not. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1675 / 1682

页数：8

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