Platelet-activating-factor-mediated pathogenesis in Lyme disease

被引：6

作者：

Isogai, E

Kimura, K

Fujii, N

Nishikawa, T

Ishii, N

Postic, D

Baranton, G

Isogai, H

机构：

[1] SAPPORO MED UNIV, DEPT MICROBIOL, SAPPORO, HOKKAIDO 060, JAPAN

[2] SAPPORO MED UNIV, DIV ANIM EXPERIMENTAT, SAPPORO, HOKKAIDO 060, JAPAN

[3] YOKOHAMA CITY UNIV, SCH MED, DEPT DERMATOL, YOKOHAMA, KANAGAWA 234, JAPAN

[4] INST PASTEUR, UNITE BACTERIOL MOLEC & MED, PARIS 15, FRANCE

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 03期

关键词：

D O I：

10.1128/IAI.64.3.1026-1029.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study describes a role of platelet-activating factor (PAF) as a potential induces of inflammation In infection with Borrelia burgdorferi. Two approaches were taken. The first involved the use of a PAF antagonist to show the lack of an inflammatory response in skin lesions, The second was to show that the PAF antagonist reduced platelet aggregation when the spirochetes were incubated with polymorphonuclear leukocytes.

引用

页码：1026 / 1029

页数：4

共 34 条

[1] OXYGEN RADICALS INHIBIT HUMAN PLASMA ACETYLHYDROLASE, THE ENZYME THAT CATABOLIZES PLATELET-ACTIVATING-FACTOR [J].