The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

被引：185

作者：

Loenarz, Christoph ^{[1
,2
]}

Coleman, Mathew L. ^{[3
]}

Boleininger, Anna ^{[1
,2
]}

Schierwater, Bernd ^{[4
]}

Holland, PeterW. H. ^{[5
]}

Ratcliffe, Peter J. ^{[3
]}

Schofield, Christopher J. ^{[1
,2
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Oxford, Oxford Ctr Integrat Syst Biol, Oxford OX1 3TA, England

[3] Univ Oxford, Oxford OX3 7BN, England

[4] Tierarztliche Hsch Hannover, Inst Tierokol & Zellbiol, D-30559 Hannover, Germany

[5] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

EMBO REPORTS | 2011年 / 12卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

evolution; HIF; hypoxia; oxygen sensing; Trichoplax; PROLYL HYDROXYLASE; BINDING; DEGRADATION; VARIANT; GENOME; CELLS;

D O I：

10.1038/embor.2010.170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.

引用

页码：63 / 70

页数：8

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