Stereocontrolled synthesis of cyclopropanol amino acids from allylic sulfones:: Conformationally restricted building blocks

被引：24

作者：

Díez, D

Garcia, P

Marcos, IS

Garrido, NM

Basabe, P

Broughton, HB

Urones, JG

机构：

[1] Univ Salamanca, Dept Quim Organ, E-37008 Salamanca, Spain

[2] Lilly SA, Madrid 28108, Spain

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 20期

关键词：

D O I：

10.1021/ol035451d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new amino acid methyl ester with a cyclopropanol has been synthesized starting from the allyl sulfone 10. The starting material, 10, could be obtained in both enantiomeric forms. The stereoselectivity of the cyclopropane formation has been studied by molecular modeling.

引用

页码：3687 / 3690

页数：4

共 21 条

[1] Stereocontrolled synthesis of 3-(trans-2-aminocyclopropyl)alanine, a key component of belactosin A [J].