Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population

被引：128

作者：

Murata, M

Watanabe, M

Yamanaka, M

Kubota, Y

Ito, H

Nagao, M

Katoh, T

Kamataki, T

Kawamura, J

Yatani, R

Shiraishi, T

机构：

[1] Mie Univ, Sch Med, Dept Pathol 2, Tsu, Mie 514, Japan

[2] Mie Univ, Sch Med, Dept Urol, Tsu, Mie 514, Japan

[3] Yokohama City Univ, Sch Med, Dept Urol, Yokohama, Kanagawa, Japan

[4] Chiba Univ, Sch Med, Dept Urol, Chiba, Japan

[5] Natl Canc Ctr, Div Biochem, Tokyo, Japan

[6] Miyazaki Med Coll, Dept Publ Hlth, Miyazaki, Japan

[7] Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Drug Metabol, Div Pharmacobio Dynam, Sapporo, Hokkaido, Japan

来源：

CANCER LETTERS | 2001年 / 165卷 / 02期

关键词：

prostate cancer; glutathione S-transferase; cytochrome P-450; polymorphism;

D O I：

10.1016/S0304-3835(01)00398-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Associations between genetic polymorphisms of CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 and prostate cancer (PCa) were analyzed in a case-control study of 315 individuals. The frequency of valine (Val)/valine (Val) genotypes for CYP1A1 was 11.3% in cases compared with 5.5% in controls, this polymorphism thus being associated with a significantly increased risk of PCa (odds ratio = 2.4, 95% confidence interval (CI) = 1.01-5.57). No links were detected between PCa and polymorphisms in other enzymes. However, the combination of CYP1A1 (Ile/Val and/or Val/Val) polymorphisms with the GSTM1 null type resulted in an OR of 2.2 (CI = 1.10-4.57, 1.12-4.20, respectively). This study suggests that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：171 / 177

页数：7

共 29 条

[1] HUMAN CYTOCHROME P-450PA (P-450IA2), THE PHENACETIN O-DEETHYLASE, IS PRIMARILY RESPONSIBLE FOR THE HEPATIC 3-DEMETHYLATION OF CAFFEINE AND N-OXIDATION OF CARCINOGENIC ARYLAMINES - (AROMATIC-AMINES HETEROCYCLIC AMINES CARCINOGEN METABOLISM) [J].