Sox9 induces testis development in XX transgenic mice

被引：519

作者：

Vidal, VPI

Chaboissier, MC

de Rooij, DG

Schedl, A

机构：

[1] MDC Mol Med, D-13092 Berlin, Germany

[2] Univ Utrecht, Med Ctr, Dept Cell Biol, Utrecht, Netherlands

来源：

NATURE GENETICS | 2001年 / 28卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/90046

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutations in SOX9 are associated with male-to-female sex reversal in humans(1,2). To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.

引用

收藏

页码：216 / 217

页数：2

相关论文

共 20 条

[1] Targeted mutagenesis of the endogenous mouse Mis gene promoter:: In vivo definition of genetic pathways of vertebrate sexual development [J].

Arango, NA ;

Lovell-Badge, R ;

Behringer, RR .

CELL, 1999, 99 (04) :409-419

[2]

Bergstrom DE, 2000, GENESIS, V28, P111, DOI 10.1002/1526-968X(200011/12)28:3/4<111::AID-GENE40>3.0.CO

[3]

2-5

[4] A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse [J].

Bishop, CE ;

Whitworth, DJ ;

Qin, YJ ;

Agoulnik, AI ;

Agoulnik, IU ;

Harrison, WR ;

Behringer, RR ;

Overbeek, PA .

NATURE GENETICS, 2000, 26 (04) :490-494

[5] Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds [J].

daSilva, SM ;

Hacker, A ;

Harley, V ;

Goodfellow, P ;

Swain, A ;

LovellBadge, R .

NATURE GENETICS, 1996, 14 (01) :62-68

[6] Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene [J].

De Santa Barbara, P ;

Bonneaud, N ;

Boizet, B ;

Desclozeaux, M ;

Moniot, B ;

Sudbeck, P ;

Scherer, G ;

Poulat, F ;

Berta, P .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6653-6665

[7] CAMPOMELIC DYSPLASIA AND AUTOSOMAL SEX REVERSAL CAUSED BY MUTATIONS IN AN SRY-RELATED GENE [J].

FOSTER, JW ;

DOMINGUEZSTEGLICH, MA ;

GUIOLI, S ;

KWOK, C ;

WELLER, PA ;

STEVANOVIC, M ;

WEISSENBACH, J ;

MANSOUR, S ;

YOUNG, ID ;

GOODFELLOW, PN ;

BROOK, JD ;

SCHAFER, AJ .

NATURE, 1994, 372 (6506) :525-530

[8]

Huang B, 1999, AM J MED GENET, V87, P349, DOI 10.1002/(SICI)1096-8628(19991203)87:4<349::AID-AJMG13>3.0.CO

[9]

2-N

[10]

Hunt PA, 1998, MOL REPROD DEV, V49, P101, DOI 10.1002/(SICI)1098-2795(199802)49:2&lt