TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles

被引：145

作者：

Llovera, M ^{[1
]}

GarciaMartinez, C ^{[1
]}

Agell, N ^{[1
]}

LopezSoriano, FJ ^{[1
]}

Argiles, JM ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & BIOL MOL,BARCELONA 7,SPAIN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 230卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.5827

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incubation of isolated rat soleus muscles in the presence of human recombinant TNF-alpha(10,000 U/ml) resulted in an important increase in ubiquitin gene expression (over 50%). Although previous studies involving cytokine administration in vivo (1) have demonstrated an action on ubiquitin-dependent proteolysis, this is the first report demonstrating a direct action of the cytokine on protein breakdown in incubated rat skeletal muscle. (C) 1997 Academic Press

引用

页码：238 / 241

页数：4

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