Correlation between serum linezolid concentration and the development of thrombocytopenia

被引：69

作者：

Hiraki, Yoichi ^{[1
]}

Tsuji, Yasuhiro ^{[2
]}

Hiraike, Mikako ^{[1
]}

Misumi, Nobuhiro ^{[1
]}

Matsumoto, Kana ^{[3
]}

Morita, Kunihiko ^{[3
]}

Kamimura, Hidetoshi ^{[4
]}

Karube, Yoshiharu ^{[4
]}

机构：

[1] Natl Hosp Org, Dept Pharm, Kumamoto Med Ctr, Kumamoto 8600008, Japan

[2] Sasebo Chuo Hosp, Dept Pharm, Sasebo, Nagasaki, Japan

[3] Doshisha Womens Coll Liberal Arts, Dept Clin Pharmaceut, Fac Pharmaceut Sci, Kyoto, Japan

[4] Fukuoka Univ, Fac Pharmaceut Sci, Johnan Ku, Fukuoka 81401, Japan

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2012年 / 44卷 / 01期

关键词：

Dose-response curve; linezolid; logit analysis; renal dysfunction; thrombocytopenia; HIGH-FREQUENCY;

D O I：

10.3109/00365548.2011.608712

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 mu g/ml.

引用

页码：60 / 64

页数：5

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