Neuroprotective strategies for the neonatal brain

被引：53

作者：

Degos, Vincent ^{[1
,2
,3
]}

Loron, Gauthier ^{[1
,2
,3
]}

Mantz, Jean ^{[1
,2
,3
,4
]}

Gressens, Pierre ^{[1
,2
,3
,5
]}

机构：

[1] Hop Robert Debre, INSERM, U676, F-75019 Paris, France

[2] Univ Paris 07, Fac Med Denis Diderot, IFR02, Paris, France

[3] Univ Paris 07, Fac Med Denis Diderot, IFR25, Paris, France

[4] Hop Beaujon, AP HP, Dept Anesthesie Reanimat, Clichy, France

[5] Hop Robert Debre, AP HP, Serv Neurol Pediat, F-75019 Paris, France

来源：

ANESTHESIA AND ANALGESIA | 2008年 / 106卷 / 06期

关键词：

D O I：

10.1213/ane.0b013e3181733f6f

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 wk gestational age, and to corticosubcortical lesions, which occur mainly in full-term infants. Despite recent improvements in neonatal care, no effective treatment for perinatal brain lesions is available. Several interventions, such as magnesium sulfate in preterm newborns and hypothermia in term newborns, are the focus of completed or continuing clinical trials. Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review.

引用

页码：1670 / 1680

页数：11

共 135 条

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