Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages

被引：25

作者：

Abad, MJ ^{[1
]}

Bermejo, P ^{[1
]}

Alvarez, M ^{[1
]}

Guerra, JA ^{[1
]}

Silván, AM ^{[1
]}

Villar, AM ^{[1
]}

机构：

[1] Univ Complutense, Fac Pharm, Dept Pharmacol, E-28040 Madrid, Spain

来源：

PLANTA MEDICA | 2004年 / 70卷 / 01期

关键词：

Tanacetum microphyllum; Compositae; lipopolysaccharide; prostaglandin E-2; nitric oxide; tumour necrosis factor-alpha;

D O I：

10.1055/s-2004-815452

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in a concentration-dependent manner. In the tumour necrosis factor-alpha (TNF-alpha) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-alpha. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.

引用

页码：34 / 38

页数：5

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