Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage

被引：34

作者：

Britt-Compton, B. ^{[1
]}

Lin, T. T. ^{[1
]}

Ahmed, G. ^{[2
]}

Weston, V. ^{[2
]}

Jones, R. E. ^{[1
]}

Fegan, C. ^{[3
]}

Oscier, D. G. ^{[4
]}

Stankovic, T. ^{[2
]}

Pepper, C. ^{[3
]}

Baird, D. M. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Dept Pathol, Cardiff, S Glam, Wales

[2] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham, W Midlands, England

[3] Cardiff Univ, Sch Med, Dept Haematol, Cardiff, S Glam, Wales

[4] Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England

来源：

LEUKEMIA | 2012年 / 26卷 / 04期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; SURVIVAL; ABERRATIONS; DYSFUNCTION; LENGTH; CELLS;

D O I：

10.1038/leu.2011.281

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：826 / 830

页数：6

共 8 条

[1] Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion [J].

Austen, Belinda ;

Skowronska, Anna ;

Baker, Claire ;

Powell, Judith E. ;

Gardiner, Anne ;

Oscier, David ;

Majid, Aneela ;

Dyer, Martin ;

Siebert, Reiner ;

Taylor, A. Malcolm ;

Moss, Paul A. ;

Stankovic, Tatjana .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (34) :5448-5457

[2] Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells [J].

Brugat, Thibaut ;

Nguyen-Khac, Florence ;

Grelier, Aurore ;

Merle-Beral, Helene ;

Delic, Jozo .

BLOOD, 2010, 116 (02) :239-249

[3] Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations [J].

Damle, RN ;

Batliwalla, FM ;

Ghiotto, F ;

Valetto, A ;

Albesiano, E ;

Sison, C ;

Allen, SL ;

Kolitz, J ;

Vinciguerra, VP ;

Kudalkar, P ;

Wasil, T ;

Rai, KR ;

Ferrarini, M ;

Gregersen, PK ;

Chiorazzi, N .

BLOOD, 2004, 103 (02) :375-382

[4] Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis [J].

Lin, Thet Thet ;

Letsolo, Boitelo T. ;

Jones, Rhiannon E. ;

Rowson, Jan ;

Pratt, Guy ;

Hewamana, Saman ;

Fegan, Chris ;

Pepper, Chris ;

Baird, Duncan M. .

BLOOD, 2010, 116 (11) :1899-1907

[5]

Messmer BT, 2005, J CLIN INVEST, V115, P755, DOI 10.1172/JCI200523409

[6] Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia [J].

Roos, Goran ;

Kroeber, Alexander ;

Grabowski, Pawel ;

Kienle, Dirk ;

Buehler, Andreas ;

Doehner, Hartmut ;

Rosenquist, Richard ;

Stilgenbauer, Stephan .

BLOOD, 2008, 111 (04) :2246-2252

[7] Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia [J].

Rossi, D. ;

Bodoni, C. Lobetti ;

Genuardi, E. ;

Monitillo, L. ;

Drandi, D. ;

Cerri, M. ;

Deambrogi, C. ;

Ricca, I. ;

Rocci, A. ;

Ferrero, S. ;

Bernocco, E. ;

Capello, D. ;

De Paoli, L. ;

Bergui, L. ;

Boi, M. ;

Omede, P. ;

Massaia, M. ;

Tarella, C. ;

Passera, R. ;

Boccadoro, M. ;

Gaidano, G. ;

Ladetto, M. .

LEUKEMIA, 2009, 23 (06) :1062-1072

[8] ATM-like kinases and regulation of telomerase: lessons from yeast and mammals [J].

Sabourin, Michelle ;

Zakian, Virginia A. .

TRENDS IN CELL BIOLOGY, 2008, 18 (07) :337-346

← 1 →