Peroxynitrite: A biologically significant oxidant

被引：152

作者：

Murphy, MP ^{[1
]}

Packer, MA ^{[1
]}

Scarlett, JL ^{[1
]}

Martin, SW ^{[1
]}

机构：

[1] Univ Otago, Dept Biochem, Dunedin, New Zealand

来源：

GENERAL PHARMACOLOGY | 1998年 / 31卷 / 02期

关键词：

peroxynitrite; nitric oxide; superoxide; oxidative stress;

D O I：

10.1016/S0306-3623(97)00418-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3. In this review, we outline the properties of peroxynitrite and discuss how it can affect biological systems and contribute to human pathologies, (C) 1998 Elsevier Science Inc.

引用

收藏

页码：179 / 186

页数：8

相关论文

共 112 条

[1] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[2] SPIN-TRAPPING STUDIES OF PEROXYNITRITE DECOMPOSITION AND OF 3-MORPHOLINOSYDNONIMINE N-ETHYLCARBAMIDE AUTOOXIDATION - DIRECT EVIDENCE FOR METAL-INDEPENDENT FORMATION OF FREE-RADICAL INTERMEDIATES [J].

AUGUSTO, O ;

GATTI, RM ;

RADI, R .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 310 (01) :118-125

[3] TURNING ON THE RESPIRATORY BURST [J].

BAGGIOLINI, M ;

WYMANN, MP .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (02) :69-72

[4] Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: Implications for neuronal astrocytic trafficking and neurodegeneration [J].

Barker, JE ;

Bolanos, JP ;

Land, JM ;

Clark, JB ;

Heales, SJR .

DEVELOPMENTAL NEUROSCIENCE, 1996, 18 (5-6) :391-396

[5] IMMUNOCYTOCHEMICAL EVIDENCE FOR A MITOCHONDRIALLY LOCATED NITRIC-OXIDE SYNTHASE IN BRAIN AND LIVER [J].

BATES, TE ;

LOESCH, A ;

BURNSTOCK, G ;

CLARK, JB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 213 (03) :896-900

[6]

BECKMAN J, 1994, BIOCHEMIST OCT, P8

[7] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[8]

Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424

[9] KINETICS OF SUPEROXIDE DISMUTASE-CATALYZED AND IRON-CATALYZED NITRATION OF PHENOLICS BY PEROXYNITRITE [J].

BECKMAN, JS ;

ISCHIROPOULOS, H ;

ZHU, L ;

VANDERWOERD, M ;

SMITH, C ;

CHEN, J ;

HARRISON, J ;

MARTIN, JC ;

TSAI, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) :438-445

[10]

BECKMAN JS, 1994, ANN NY ACAD SCI, V738, P69

← 1 2 3 4 5 6 7 8 9 10 →