Oligoagarose-g-polycaprolactone loaded nanoparticles for drug delivery applications

被引：10

作者：

Bhaw-Luximon, Archana ^{[1
]}

Meeram, Laila Musharat ^{[1
]}

Jugdawa, Yeshma ^{[1
]}

Helbert, William ^{[2
]}

Jhurry, Dhanjay ^{[1
]}

机构：

[1] Fac Sci, Dept Chem, Reduit, Mauritius

[2] UPMC, CNRS, UMR Vegetaux Marins & Biomol 7139, Equipe Struct Polysaccharides Marins,Stn Biol, F-29682 Roscoff, France

来源：

POLYMER CHEMISTRY | 2011年 / 2卷 / 01期

关键词：

CHITOSAN NANOPARTICLES; DIBLOCK COPOLYMER; BLOCK-COPOLYMERS; RELEASE; KETOPROFEN; MICELLES; CARRIERS; DEXTRAN;

D O I：

10.1039/c0py00311e

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Well-defined oligoagarose-g-polycaprolactone copolymers of varying PCL chain lengths have been synthesised using protection/deprotection chemistry. The graft copolymers showed amphiphilic behaviour with spherical micelles in the size range 10 to 20 nm. Ketoprofen was loaded into the core of the micelles. The drug loading efficiency was shown to increase with the length of the hydrophobic PCL chain: 2% for PCL10 and 5.5% for PCL15. Sustained drug release was observed over a period of 72 h and was faster with shorter PCL chains.

引用

收藏

页码：77 / 79

页数：3

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