The "triamino-analogue" of methyl cholate; A facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry

被引：48

作者：

Broderick, S ^{[1
]}

Davis, AP ^{[1
]}

Williams, RP ^{[1
]}

机构：

[1] Trinity Coll, Dept Chem, Dublin 2, Ireland

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(98)01254-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The triamino steroid 2 is synthesized from cholic acid (1), and found to possess little tendency to aggregate at pH 5 - 6 in aqueous solution. 2 and/or related derivatives are expected to find use in the synthesis of receptors and combinatorial libraries, and as "contrafacial amphiphiles" for drug delivery across cell membranes. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：6083 / 6086

页数：4

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