Synthesis of novel chiral quaternary phosphonium fluorides: reagents for simple asymmetric nucleophilic fluorination reactions

被引：12

作者：

Beaumont, AJ ^{[1
]}

Kiely, C ^{[1
]}

Rooney, AD ^{[1
]}

机构：

[1] Natl Univ Ireland Maynooth, Dept Chem, Maynooth, Kildare, Ireland

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2001年 / 108卷 / 01期

关键词：

asymmetric; nucleophilic; fluorination; chiral; phosphonium; fluoride;

D O I：

10.1016/S0022-1139(00)00401-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The novel chiral quaternary salt (R-P)-benzylmenthylmethylphenylphosphonium fluoride was synthesised. The compound was used in the asymmetric nucleophilic fluorination of 2-bromopropiophenone to give 7-fluoropropiophenone in a 35% yield with [alpha](D)(20) = +1.94 degrees. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：47 / 50

页数：4

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