Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression

被引：86

作者：

Bonet, ML

Oliver, J

Picó, C

Felipe, F

Ribot, J

Cinti, S

Palou, A

机构：

[1] Univ Illes Balears, Dept Biol Fonamental & Ciencies Salut, Lab Biol Mol Nutr & Biotecnol, Palma de Mallorca 07071, Spain

[2] Univ Ancona, Fac Med & Chirurg, Ist Morfol Umana Normale, I-60020 Ancona, Italy

来源：

JOURNAL OF ENDOCRINOLOGY | 2000年 / 166卷 / 03期

关键词：

D O I：

10.1677/joe.0.1660511

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationship between interscapular brown adipose tissue (IBAT) thermogenic potential and Vitamin A status was investigated by studying the effects of feeding a vitamin A-deficient diet and all-trans retinoic acid (tRA) treatment on body weight and IBAT parameters in mice. Feeding a vitamin A-deficient diet tended to trigger opposite effects to those of tRA treatment, namely increased body weight, IBAT weight, adiposity and leptin mRNA expression, and reduced IBAT thermogenic potential in terms of uncoupling protein 1 (UCP1) mRNA and UCP2 mRNA expression. The results emphasize the importance of retinoids as physiological regulators of brown adipose tissue.

引用

页码：511 / 517

页数：7

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