Cord blood plasma reference intervals for potential sepsis markers: Pro-adrenomedullin, pro-endothelin, and pro-atrial natriuretic peptide

被引：23

作者：

Miguel, Diego

Prieto, Belen ^{[1
]}

Costa, Marta ^{[2
]}

Coto, Daniel ^{[2
]}

Alvarez, Francisco V. ^{[3
]}

机构：

[1] Hosp Univ Cent Asturias, Serv Bioquim Clin, Clin Biochem Lab, Oviedo 33006, Spain

[2] Hosp Univ Cent Asturias, Serv Pediat, Oviedo 33006, Spain

[3] Univ Oviedo, Dept Biochem & Mol Biol, Asturias, Spain

来源：

CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 04期

关键词：

Neonatal sepsis; MR-proADM (mid-regional fragment of pro-adrenomedullin); MR-proANP (mid-regional fragment of pro-atrial natriuretic peptide); CT-proET-1 (carboxy-terminal fragment of pro-endothelin-1); PCT (procalcitonin); PROCALCITONIN CONCENTRATIONS; SERUM PROCALCITONIN; PROGNOSTIC MARKER; NEONATAL SEPSIS; DIAGNOSIS; PROADRENOMEDULLIN; PRECURSOR;

D O I：

10.1016/j.clinbiochem.2010.12.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To establish reference values in cord blood of the following new sepsis markers: proadrenomedullin (MR-proADM), pro-endothelin (CT-proET-1), and pro-atrial natriuretic peptide (MR-proANP). Methods: MR-proADM, CT-proET-1, MR-proANP, and procalcitonin (PCT) were measured in cord blood of newborn infants by Time Resolved Amplified Cryptate Emission (TRACE) technology. The inclusion criteria in the control group (n = 194) was the absence of any clinical sign or risk factor of sepsis. A group of 73 newborn infants presenting with risk factors of sepsis at delivery was also studied. Results: The median values (reference interval) of CT-proET-1, MR-pro-ADM, and MR-proANP measured in cord blood plasma were 72 pmol/L (39-115), 0.84 nmol/L (0.5-1.38), and 163 pmol/L (76-389), respectively. The PCT reference interval was not significantly different from that previously described in cord blood serum. Conclusions: The reference intervals established will serve as a starting point for further clinical investigations aimed to elucidate the potential prognostic/diagnostic value of these markers in neonatal sepsis management. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：337 / 341

页数：5

共 35 条

[1] Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides [J].