Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necfosis factor-related apoptosis-inducing ligand (TRAIL)

被引：21

作者：

Oehadian, A ^{[1
]}

Koide, N ^{[1
]}

Mu, MM ^{[1
]}

Hassan, F ^{[1
]}

Islam, S ^{[1
]}

Yoshida, T ^{[1
]}

Yokochi, T ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Microbiol & Immunol, Nagakute, Aichi 4801195, Japan

来源：

CANCER LETTERS | 2005年 / 225卷 / 01期

关键词：

IFN-beta-; DHL-4; cells; apoptosis; TRAIL; diffuse large B lymphoma;

D O I：

10.1016/j.canlet.2004.11.054

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of interferon (IFN)-alpha, beta and gamma on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-beta significantly inhibited the cell growth, and the effect was stronger than that of IFN-alpha. IFN-gamma did not inhibit the cell growth because of lack of IFN-gamma receptors. IFN-beta caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-beta lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-beta-induced apoptosis. It was suggested that IFN-beta might cause apoptosis in DHL-4 cells through TRAIL. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：85 / 92

页数：8

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