Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC 12 cells

被引：39

作者：

Heo, H. J. ^{[1
]}

Choi, S. J. ^{[1
]}

Choi, S. -G. ^{[2
]}

Shin, D. -H. ^{[2
]}

Lee, J. M. ^{[3
]}

Lee, C. Y. ^{[4
]}

机构：

[1] Gyeongsang Natl Univ, Inst Agr & Life Sci, Div Appl Life Sci, Jinju 660701, Gyeongnam, South Korea

[2] Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea

[3] Kyung Hee Univ, Grad Sch EW Med Sci, Dept Med Nutr, Yongin 449701, Gyeonggi, South Korea

[4] Cornell Univ, Dept Food Sci & Technol, Geneva, NY 14456 USA

来源：

JOURNAL OF FOOD SCIENCE | 2008年 / 73卷 / 02期

关键词：

apple; banana; neurotoxicity; orange; oxidative stress;

D O I：

10.1111/j.1750-3841.2007.00632.x

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Banana, orange, and apple are the major fruits in Western and Asian diets. In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H2O2 treatment. We found a significant viability of PC 12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.

引用

页码：H28 / H32

页数：5

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