Elevated number of cells secreting transforming growth factor β in Guillain-Barre syndrome

被引：14

作者：

Dahle, C ^{[1
]}

Kvarnström, M

Ekerfelt, C

Samuelsson, M

Ernerudh, J

机构：

[1] Linkoping Univ Hosp, Fac Hlth Sci, Dept Mol & Clin Med, Div Clin Immunol, SE-58185 Linkoping, Sweden

[2] Linkoping Univ Hosp, Fac Hlth Sci, Dept Neurosci & Locomot, Div Neurol, SE-58185 Linkoping, Sweden

[3] Orebro Univ Hosp, Neurol Unit, Orebro, Sweden

来源：

APMIS | 2003年 / 111卷 / 12期

关键词：

Guillain-Barre syndrome; cytokines; TGF-beta; IL-4; ELISPOT;

D O I：

10.1111/j.1600-0463.2003.apm1111204.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-gamma, TGF-beta, IL-6, and TNF-alpha by circulating mononuclear cells during the course of Guillain-Barre syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-beta-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-beta secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-gamma, IL-6 or TNF-alpha. Our findings indicate a down-regulatory role for TGF-beta and IL-4 in GBS.

引用

页码：1095 / 1104

页数：10

共 52 条

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