Mechanisms of Aβ clearance and catabolism

被引：29

作者：

Guénette, SY ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Mass Gen Inst Neurodegenerat Dis, Charlestown, MA 02129 USA

来源：

NEUROMOLECULAR MEDICINE | 2003年 / 4卷 / 03期

关键词：

beta-amyloid; degradation; clearance; Alzheimer's disease;

D O I：

10.1385/NMM:4:3:147

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mutations that result in an increased generation of amyloid beta peptide (Abeta) account for less than 5% of Alzheimer's disease (AD). Data suggesting that late onset AD risk factors play a role in Abeta turnover in the brain have shifted some of the research focus to the study of Abeta clearance and degradation and the impact of these processes on the etiology of Alzheimer's disease (AD). This review will examine the data obtained from studies performed in knockout and transgenic mice on the proteases; the cells and the physiological mechanisms that play a part in the removal of Abeta from the brain.

引用

页码：147 / 160

页数：14

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