Synthesis of a novel series of 6-chloro-1,4,2-benzodithiazine 1,1-dioxide derivatives with potential biological activity

被引：7

作者：

Brzozowski, Z ^{[1
]}

Saczewski, F ^{[1
]}

机构：

[1] Med Acad Gdansk, Dept Chem Technol Drugs, PL-80416 Gdansk, Poland

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 07期

关键词：

D O I：

10.1002/jhet.5570420708

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of 6-chloro-1,4,2-benzodithiazine 1,1-dioxide derivatives 2-19 with alkyl, aryl or heteroaryl substituents at position 3 have been synthesized by the reaction of 4-chloro-2-mercaptobenzenesulfonamides with aldehydes, aldehyde acetals or acid anhydrides. 6-Chloro-3-(2-hydroxyphenyl)-7-methyl-2,3-dihydro-1,4,2-benzodithiazine 1,1-dioxide (7) exhibited remarkable activity on the leukemia CCRF-CEM cell line (GI(50)<10 nM) and moderate activity against the other 49 human tumor cell lines derived from nine different cancer type.

引用

页码：1297 / 1303

页数：7

共 21 条

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