Genetic control of skeletal development

被引：194

作者：

Wagner, EF

Karsenty, G

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

[2] Baylor Coll Med, Houston, TX 77030 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(00)00228-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The skeleton is a single organ composed of > 200 different elements spread throughout the body. These skeletal elements comprise two tissues: cartilage and bone. Both tissues contain specific cell type(s): chondrocytes in cartilage and osteoblasts and osteoclasts in bone. We are beginning to understand the genetic control of the differentiation and function of these cells through recent developments in mouse and human genetics, and also through the use of molecular biological and biochemical techniques. The most recent advances in terms of cell differentiation in the skeleton are presented in this review.

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页码：527 / 532

页数：6

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