Synthesis of 6- or 7-hydroxy and 6- or 7-methoxy tropanes

被引：11

作者：

Chen, ZM ^{[1
]}

Meltzer, PC ^{[1
]}

机构：

[1] ORGANIX INC,WOBURN,MA 01801

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(97)00087-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Mannich type condensation between the monomethyl ester of acetonedicarboxylic acid, methylamine hydrochloride. and hydrolyzed dimethoxydihydrofuran gave 6- or 7-functionalized beta-keto ester tropanes 12 - 15. Further elaboration afforded a series of 6- or 7-hydroxy and 6- or 7-methoxy 2 beta-methoxycarbonyl-3-aryltropanes. (C) 1997, Elsevier Science Ltd.

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页码：1121 / 1124

页数：4

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