Scaffold composition and biological relevance of screening libraries

被引：142

作者：

Shelat, Anang A. ^{[1
]}

Guy, R. Kiplin ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38103 USA

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 08期

关键词：

D O I：

10.1038/nchembio0807-442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

引用

页码：442 / 446

页数：5

共 34 条

[1] Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters [J].

Beeler, AB ;

Acquilano, DE ;

Su, QB ;

Yan, F ;

Roth, BL ;

Panek, JS ;

Porco, JA .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2005, 7 (05) :673-681

[2] The properties of known drugs .1. Molecular frameworks [J].

Bemis, GW ;

Murcko, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) :2887-2893

[3] Focused library design in GPCR projects on the example of 5-HT2c agonists:: Comparison of structure-based virtual screening with ligand-based search methods [J].

Bissantz, C ;

Schalon, C ;

Guba, W ;

Stahl, M .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 61 (04) :938-952

[4]

BONCHEV D, 2007, CHEM INF MODEL, V47, P909

[5] Selection of heterocycles for drug design [J].

Broughton, HB ;

Watson, IA .

JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2004, 23 (01) :51-58

[6] A planning strategy for diversity-oriented synthesis [J].

Burke, MD ;

Schreiber, SL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58

[7] A synthesis strategy yielding skeletally diverse small molecules combinatorially [J].

Burke, MD ;

Berger, EM ;

Schreiber, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (43) :14095-14104

[8] A rule of three for fragment-based lead discovery? [J].

Congreve, M ;

Carr, R ;

Murray, C ;

Jhoti, H .

DRUG DISCOVERY TODAY, 2003, 8 (19) :876-877

[9] Privileged structures as leads in medicinal chemistry [J].

Costantino, L ;

Barlocco, D .

CURRENT MEDICINAL CHEMISTRY, 2006, 13 (01) :65-85

[10] Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics [J].

Dekker, FJ ;

Koch, MA ;

Waldmann, H .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (03) :232-239

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