Finding of endocannabinoids in human eye tissues: implications for glaucoma

被引：89

作者：

Chen, J ^{[1
]}

Matias, I

Dinh, T

Lu, T

Venezia, S

Nieves, A

Woodward, DF

Di Marzo, V

机构：

[1] CNR, Inst Biomol Chem, Endocannabinoid Res Grp, Pozzuoli, Napoli, Italy

[2] Allergan Pharmaceut Inc, Dept Biol Sci, Irvine, CA USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 330卷 / 04期

关键词：

2-arachidonoylglycerol anandamide; palmitoylcthanolamide; eye; human; glaucoma;

D O I：

10.1016/j.bbrc.2005.03.095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cannabinoid CB, receptors are involved in ocular physiology and may regulate intraocular pressure (IOP). However, endocannabinoid levels in human ocular tissues of cornea, iris, ciliary body, retina, and choroid from normal and glaucomatous donors have not been investigated. Anandamide (A-arachidonoylethanolamine; AEA), 2-arachidonoylglycerol (2-AG), and the anandamide congener, palmitoylethanolamide (PEA), were detected in all the human tissues examined. In eyes from patients with glaucoma, significantly decreased 2-AG and PEA levels were detected in the ciliary body, an important tissue in the regulation of IOP. The findings suggest that these endogenous compounds may have a role in this disease, particularly with respect to regulation of IOP. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1062 / 1067

页数：6

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