A nitric oxide synthase inhibitor NG-nitro-L-arginine, attenuates glucoprivic feeding and deprivation-induced drinking in the mouse

被引:19
作者
Czech, DA [1 ]
机构
[1] Marquette Univ, Dept Psychol, Biopsychol Lab, Milwaukee, WI 53201 USA
关键词
2-deoxy-D-glucose; 2DG; D-arginine; delayed feeding; drinking; glucoprivation; food intake; feeding behavior; insulin; L-arginine; L-NOARG; mice; N-G-nitro-L-arginine; nitric oxide; nitric oxide synthase inhibitor; water intake;
D O I
10.1016/S0091-3057(98)00016-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Possible involvement of nitric oxide (NO) in glucoprivic hyperphagia was investigated in nondeprived male ICR mice in independent groups designs. One pair of experiments demonstrated dose-related reductions in 2-deoxy-D-glucose (2DG)- and insulin-induced solid food intake with increasing dose (10, 25, and 50 mg/kg SC) of the NO-synthase (NOS) inhibitor, N-G-nitro-L-arginine (L-NOARG), reaching statistical significance at 10 mg/kg L-NOARG when compared to vehicle controls. In a second pair of experiments, initial pre treatment with L-arginine (500 and 1000 mg/kg TP) partially or completely restored the feeding inhibitory action of an effective challenge dose (25 mg/kg) of L-NOARG; D-arginine (500 mg/kg LP) was ineffective, thus supporting a stereospecific action of arginine. A third set of experiments demonstrated dose-related reduction in glucoprivic feeding under delayed access (4 or 6 h) to food. These findings suggest involvement of NO in glucoprivic hyperphagia; they are consistent with and extend research linking NO and ingestive behaviors through use of NOS inhibitors. Deprivation-induced drinking was attenuated by these doses of L-NOARG as well. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:601 / 607
页数:7
相关论文
共 38 条
[1]   NALTREXONE, SEROTONIN RECEPTOR SUBTYPE ANTAGONISTS, AND GLUCOPRIVIC INTAKE .1. 2-DEOXY-D-GLUCOSE [J].
BECZKOWSKA, IW ;
KOCH, JE ;
BODNAR, RJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1992, 42 (04) :661-670
[2]   SEROTONIN AND THE BIOLOGY OF FEEDING [J].
BLUNDELL, JE .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1992, 55 (01) :155-159
[3]   ENDOGENOUS NITRIC-OXIDE MODULATES MORPHINE-INDUCED CHANGES IN LOCOMOTION AND FOOD-INTAKE IN MICE [J].
CALIGNANO, A ;
PERSICO, P ;
MANCUSO, F ;
SORRENTINO, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 231 (03) :415-419
[4]   HYPOTHALAMIC PARAVENTRICULAR NUCLEUS LESIONS DO NOT ABOLISH GLUCOPRIVIC OR LIPOPRIVIC FEEDING [J].
CALINGASAN, NY ;
RITTER, S .
BRAIN RESEARCH, 1992, 595 (01) :25-31
[5]   NITRIC-OXIDE CONTROLS FEEDING-BEHAVIOR IN THE CHICKEN [J].
CHOI, YH ;
FURUSE, M ;
OKUMURA, J ;
DENBOW, DM .
BRAIN RESEARCH, 1994, 654 (01) :163-166
[6]   SECRETION OF GASTRIC ACID IN RESPONSE TO A LACK OF METABOLIZABLE GLUCOSE [J].
COLINJONES, DG ;
HIMSWORTH, RL .
JOURNAL OF PHYSIOLOGY-LONDON, 1969, 202 (01) :97-+
[7]   Possible involvement of nitric oxide in chlordiazepoxide-induced feeding in the mouse [J].
Czech, DA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 55 (03) :327-331
[8]  
DAWSON TM, 1994, J NEUROSCI, V14, P5147
[9]   CHANGES IN EATING BEHAVIOR AND THERMOGENIC ACTIVITY FOLLOWING INHIBITION OF NITRIC-OXIDE FORMATION [J].
DELUCA, B ;
MONDA, M ;
SULLO, A .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1995, 268 (06) :R1533-R1538
[10]   INVOLVEMENT OF NITRIC-OXIDE IN THE REFLEX RELAXATION OF THE STOMACH TO ACCOMMODATE FOOD OR FLUID [J].
DESAI, KM ;
SESSA, WC ;
VANE, JR .
NATURE, 1991, 351 (6326) :477-479