Aging as a Biological Target for Prevention and Therapy

被引：95

作者：

Barzilai, Nir ^{[1
]}

Cuervo, Ana Maria ^{[1
]}

Austad, Steve ^{[2
]}

机构：

[1] Albert Einstein Coll Med, Inst Aging Res, 1300 Morris Pk Ave,Belfer Bldg,Room701, Bronx, NY 10461 USA

[2] Univ Alabama Birmingham, Dept Biol, Birmingham, AL USA

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2018年 / 320卷 / 13期

关键词：

D O I：

10.1001/jama.2018.9562

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This Viewpoint discusses targeting fundamental biological aging processes through nutritional, genetic, and pharmacologic interventions to delay or prevent the onset or progression of multiple chronic diseases and debilities typically observed in older humans to enhance and extend both health and longevity. © 2018 American Medical Association. All rights reserved.

引用

页码：1321 / 1322

页数：2

共 10 条

[1]

[Anonymous], 2015, ADV GEROSCIENCE

[2]

Metformin as a Tool to Target Aging [J].

Barzilai, Nir ;

Crandall, Jill P. ;

Kritchevsky, Stephen B. ;

Espeland, Mark A. .

CELL METABOLISM, 2016, 23 (06) :1060-1065

[3]

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [J].

Bitto, Alessandro ;

Ito, Takashi K. ;

Pineda, Victor V. ;

LeTexier, Nicolas J. ;

Huang, Heather Z. ;

Sutlief, Elissa ;

Tung, Herman ;

Vizzini, Nicholas ;

Chen, Belle ;

Smith, Kaleb ;

Meza, Daniel ;

Yajima, Masanao ;

Beyer, Richard P. ;

Kerr, Kathleen F. ;

Davis, Daniel J. ;

Gillespie, Catherine H. ;

Snyder, Jessica M. ;

Treuting, Piper M. ;

Kaeberlein, Matt .

ELIFE, 2016, 5

[4]

Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance - The STOP-NIDDM Ttrial [J].

Chiasson, JL ;

Josse, RG ;

Gomis, R ;

Hanefeld, M ;

Karasik, A ;

Laakso, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (04) :486-494

[5]

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span [J].

Milman, Sofiya ;

Barzilai, Nir .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2016, 6 (01)

[6]

NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model [J].

Nadon, Nancy L. ;

Strong, Randy ;

Miller, Richard A. ;

Harrison, David E. .

EBIOMEDICINE, 2017, 21 :3-4

[7]

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice [J].

Roos, Carolyn M. ;

Zhang, Bin ;

Palmer, Allyson K. ;

Ogrodnik, Mikolaj B. ;

Pirtskhalava, Tamar ;

Thalji, Nassir M. ;

Hagler, Michael ;

Jurk, Diana ;

Smith, Leslie A. ;

Casaclang-Verzosa, Grace ;

Zhu, Yi ;

Schafer, Marissa J. ;

Tchkonia, Tamara ;

Kirkland, James L. ;

Miller, Jordan D. .

AGING CELL, 2016, 15 (05) :973-977

[8]

Geroscience and the trans-NIH Geroscience Interest Group, GSIG [J].

Sierra, Felipe ;

Kohanski, Ron .

GEROSCIENCE, 2017, 39 (01) :1-5

[9]

Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity [J].

St Sauver, Jennifer L. ;

Boyd, Cynthia M. ;

Grossardt, Brandon R. ;

Bobo, William V. ;

Rutten, Lila J. Finney ;

Roger, Veronique L. ;

Ebbert, Jon O. ;

Therneau, Terry M. ;

Yawn, Barbara P. ;

Rocca, Walter A. .

BMJ OPEN, 2015, 5 (02)

[10]

Xu Jiaquan, 2016, Natl Vital Stat Rep, V64, P1

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