A Temperature-Sensitive Drug Release System Based on Phase-Change Materials

被引：213

作者：

Choi, Sung-Wook ^{[1
]}

Zhang, Yu ^{[1
]}

Xia, Younan ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 43期

关键词：

drug release; fluidic devices; microbeads; phase-change materials; INJECTABLE THERMOSENSITIVE HYDROGEL; CHITOSAN; COPOLYMERS; DELIVERY; PROTEIN;

D O I：

10.1002/anie.201004057

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Melting away: Phase-change materials (PCMs) are used to encapsulate colloidal particles with FITC-dextran to demonstrate a new temperature-sensitive drug release system. As the temperature is increased to the melting point of the PCM, the particles leach out, followed by release of FITC-dextran. The initiation and rate of release can be manipulated by using different combinations of materials for the PCM and colloidal particles. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7904 / 7908

页数：5

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